Liver stiffness measurement by magnetic resonance elastography is not affected by hepatic steatosis.

ABSTRACT:

Objectives

To evaluate the relationship between biopsy-assessed hepatic steatosis, magnetic resonance imaging (MRI)-assessed proton density fat fraction (PDFF), and magnetic resonance elastography (MRE)-assessed liver stiffness measurement (LSM), in patients with or at risk for nonalcoholic fatty liver disease (NAFLD).

Methods

A retrospective study was performed, encompassing 256 patients who had a liver biopsy and MRI/MRE examination performed within 1 year. Clinical and laboratory data were retrieved from the electronic medical record. Hepatic steatosis and fibrosis were assessed by histopathological grading/staging. First, we analyzed the diagnostic performance of PDFF for distinguishing hepatic steatosis with the receiver operating characteristic analyses. Second, variab

SUBMITTER: Chen J 

PROVIDER: S-EPMC8795473 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature