Persistent Oxidative Stress and Inflammasome Activation in CD14^highCD16^- Monocytes From COVID-19 Patients.

ABSTRACT: The poor outcome of the coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is associated with systemic hyperinflammatory response and immunopathology. Although inflammasome and oxidative stress have independently been implicated in COVID-19, it is poorly understood whether these two pathways cooperatively contribute to disease severity. Herein, we found an enrichment of CD14^highCD16^- monocytes displaying inflammasome activation evidenced by caspase-1/ASC-speck formation in severe COVID-19 patients when compared to mild ones and healthy controls, respectively. Those cells also showed aberrant levels of mitochondrial superoxide and lipid peroxidation, both hallmarks of the oxidative stress response, which strongly correlated with caspase-1 activity. In addition,

SUBMITTER: Lage SL 

PROVIDER: S-EPMC8795739 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature