SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB₁ receptors.

ABSTRACT:

Background and purpose

Src homology 3-domain growth factor receptor-bound 2-like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid CB₁ receptors. SGIP1 is abundantly and principally expressed within the nervous system. SGIP1 and CB₁ receptors co-localize in axons and presynaptic boutons. SGIP1 interferes with the internalization of activated CB₁ receptors in transfected heterologous cells. Consequently, the transient association of CB₁ receptors with β-arrestin2 is enhanced and prolonged, and CB₁ receptor-mediated ERK1/2 signalling is decreased. Because of these actions, SGIP1 may modulate affect, anxiety, pain processing, and other physiological processes controlled by the endocannabinoid system (ECS).

Exp

SUBMITTER: Dvorakova M 

PROVIDER: S-EPMC8795748 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature