Structural and Functional Coupling of Calcium-Activated BK Channels and Calcium-Permeable Channels Within Nanodomain Signaling Complexes.

ABSTRACT: Biochemical and functional studies of ion channels have shown that many of these integral membrane proteins form macromolecular signaling complexes by physically associating with many other proteins. These macromolecular signaling complexes ensure specificity and proper rates of signal transduction. The large-conductance, Ca²⁺-activated K⁺ (BK) channel is dually activated by membrane depolarization and increases in intracellular free Ca²⁺ ([Ca²⁺]_i). The activation of BK channels results in a large K⁺ efflux and, consequently, rapid membrane repolarization and closing of the voltage-dependent Ca²⁺-permeable channels to limit further increases in [Ca²⁺]_i. Therefore, BK channel-mediated K^+<

SUBMITTER: Shah KR 

PROVIDER: S-EPMC8795833 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature