Therapeutic Mesenchymal Stem/Stromal Cells: Value, Challenges and Optimization.

ABSTRACT: Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular environments suitable for tissue repair and regeneration. Among several candidates, mesenchymal stem/stromal cells (MSCs) represent a critical component of stromal niches known to be involved in tissue homeostasis. In vitro, MSCs appear as fibroblast-like plastic adherent cells regardless of the tissue source. The therapeutic value of MSCs is being explored in several conditions, including immunological, inflammatory and degenerative diseases, as well as cancer. An improved understanding of their origin and function would facilitate their clinical use. The stemness of MSCs is still debated and requires further study. Several terms have been used to designate MSCs, although consensual nomencla

SUBMITTER: Najar M 

PROVIDER: S-EPMC8795900 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature