Relationship Between the Pyroptosis Pathway and Epilepsy: A Bioinformatic Analysis.

ABSTRACT:

Purpose

This study aimed to analyse the correlation between the pyroptosis pathway and epilepsy using bioinformatics analysis technology. We analyzed the expression of gasdermin D (GSDMD) and gasdermin E (GSDME), the key molecules of pyroptosis, in kainic acid-induced epileptic mice.

Methods

Weighted gene co-expression network analysis (WGCNA) was used to construct a signed co-expression network from expression data to screen gene sets closely related to epilepsy. The correlation between the module and epilepsy was verified through module conservative analysis, gene ontology (GO) annotation analysis, and correlation analysis with known epilepsy genes. We obtained currently recognized pyroptosis-related molecules through literature review, and correlation analysis was used to

SUBMITTER: Xia L 

PROVIDER: S-EPMC8795950 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature