Development and Assessment of a Predictive Score for Vertebral Compression Fracture After Stereotactic Body Radiation Therapy for Spinal Metastases.

ABSTRACT:

Importance

Vertebral compression fracture (VCF) is a potential adverse effect following treatment with stereotactic body radiation therapy (SBRT) for spinal metastases.

Objective

To develop and assess a risk stratification model for VCF after SBRT.

Design, setting, and participants

This retrospective cohort study conducted at a high-volume referral center included 331 patients who had undergone 464 spine SBRT treatments from December 2007 through October 2019. Data analysis was conducted from November 1, 2020, to August 17, 2021. Exclusions included proton therapy, prior surgical intervention, vertebroplasty, or missing data.

Exposures

One and 3 fraction spine SBRT treatments were most commonly delivered. Single-fraction treatments generally involved prescribed

SUBMITTER: Kowalchuk RO 

PROVIDER: S-EPMC8796057 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature