Accelerated and Scalable C(sp³)-H Amination via Decatungstate Photocatalysis Using a Flow Photoreactor Equipped with High-Intensity LEDs.

ABSTRACT: Carbon-nitrogen bonds are ubiquitous in biologically active compounds, prompting synthetic chemists to design various methodologies for their preparation. Arguably, the ideal synthetic approach is to be able to directly convert omnipresent C-H bonds in organic molecules, enabling even late-stage functionalization of complex organic scaffolds. While this approach has been thoroughly investigated for C(sp²)-H bonds, only few examples have been reported for the direct amination of aliphatic C(sp³)-H bonds. Herein, we report the use of a newly developed flow photoreactor equipped with high intensity chip-on-board LED technology (144 W optical power) to trigger the regioselective and scalable C(sp³)-H amination via decatungstate photocatalysis. This high-intensi

SUBMITTER: Wan T 

PROVIDER: S-EPMC8796300 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature