Modeling dependency structures in 450k DNA methylation data.

ABSTRACT: DNA methylation has been shown to be spatially dependent across chromosomes. Previous studies have focused on the influence of genomic context on the dependency structure, while not considering differences in dependency structure between individuals. We modeled spatial dependency with a flexible framework to quantify the dependency structure, focusing on inter-individual differences by exploring the association between dependency parameters and technical and biological variables. The model was applied to a subset of the Finnish Twin Cohort study (N = 1611 individuals). The estimates of the dependency parameters varied considerably across individuals, but were generally consistent across chromosomes within individuals. The variation in dependency parameters was associated with bisulphite co

SUBMITTER: Nustad HE 

PROVIDER: S-EPMC8796368 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature