AOP-helpFinder webserver: a tool for comprehensive analysis of the literature to support adverse outcome pathways development.

ABSTRACT: Adverse Outcome Pathways (AOPs) are a conceptual framework developed to support the use of alternative toxicology approaches in the risk assessment. AOPs are structured linear organizations of existing knowledge illustrating causal pathways from the initial molecular perturbation triggered by various stressors, through key events (KEs) at different levels of biology, to the ultimate health or ecotoxicological adverse outcome. Artificial intelligence can be used to systematically explore available toxicological data that can be parsed in the scientific literature. Recently a tool called AOP-helpFinder was developed to identify associations between stressors and KEs supporting thus documentation of AOPs. To facilitate the utilization of this advanced bioinformatics tool by the scientific and

SUBMITTER: Jornod F 

PROVIDER: S-EPMC8796376 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature