A systematic review of the patient burden of Crohn's disease-related rectovaginal and anovaginal fistulas.

ABSTRACT:

Background

Crohn's disease (CD)-related rectovaginal fistulas (RVFs) and anovaginal fistulas (AVFs) are rare, debilitating conditions that present a substantial disease and treatment burden for women. This systematic literature review (SLR) assessed the burden of Crohn's-related RVF and AVF, summarizing evidence from observational studies and highlighting knowledge gaps.

Methods

This SLR identified articles in PubMed and Embase that provide data and insight into the patient experience and disease burden of Crohn's-related RVF and AVF. Two trained reviewers used pre-specified eligibility criteria to identify studies for inclusion and evaluate risk of bias using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool for observational studies.

Results

SUBMITTER: Iglay K 

PROVIDER: S-EPMC8796404 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature