Clinical outcomes after treatment with direct antiviral agents: beyond the virological response in patients with previous HCV-related decompensated cirrhosis.

ABSTRACT:

Background

In HCV-infected patients with advanced liver disease, the direct antiviral agents-associated clinical benefits remain debated. We compared the clinical outcome of patients with a previous history of decompensated cirrhosis following treatment or not with direct antiviral agents from the French ANRS CO22 HEPATHER cohort.

Methods

We identified HCV patients who had experienced an episode of decompensated cirrhosis. Study outcomes were all-cause mortality, liver-related or non-liver-related deaths, hepatocellular carcinoma, liver transplantation. Secondary study outcomes were sustained virological response and its clinical benefits.

Results

559 patients met the identification criteria, of which 483 received direct antiviral agents and 76 remained untreated afte

SUBMITTER: Pageaux GP 

PROVIDER: S-EPMC8796427 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature