Inhalable antibiotic resistomes emitted from hospitals: metagenomic insights into bacterial hosts, clinical relevance, and environmental risks.

ABSTRACT:

Background

Threats of antimicrobial resistance (AMR) to human health are on the rise worldwide. Airborne fine particulate matter (PM_2.5), especially those emitted from hospitals, could serve as a substantial yet lesser-known environmental medium of inhalable antibiotic resistomes. A genome-centric understanding of the hosting bacterial taxa, mobility potential, and consequent risks of the resistomes is needed to reveal the health relevance of PM_2.5-associated AMR from clinical settings.

Results

Compared to urban ambient air PM_2.5, the hospital samples harbored nearly twice the abundance of antibiotic resistantance genes (ARGs, ~ 0.2 log₁₀(ARGs/16S rRNA gene)) in the summer and winter sampled. The profiled resistome was closely corr

SUBMITTER: Wu D 

PROVIDER: S-EPMC8796446 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature