Is methylmethacrylate toxic during pregnancy and breastfeeding?--- a systematic review.

ABSTRACT:

Introduction

Methyl methacrylate (MMA) is commonly used in the fields of dentistry and orthopaedic surgery. However, there remain concerns for the occupational hazards of MMA, particularly during pregnancy and breastfeeding.

Methods

We performed a systematic review of studies on effects that MMA may have in pregnancy in the context of exposure during orthopaedic surgery and dentistry. Review articles, studies lacking statistical data, single case reports and other evidence level V studies were excluded.

Results

Nine studies were included. One basic science study demonstrated an increase in neuronal cell lysis and shrunken cell bodies when neocortical neurons were exposed to MMA monomer. Three animal studies exposed pregnant rodents to MMA via intraperitoneal injection

SUBMITTER: Lin JS 

PROVIDER: S-EPMC8796479 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature