Identification of key genes in pathogenesis of placental insufficiency intrauterine growth restriction.

ABSTRACT:

Background

Intrauterine growth restriction (IUGR) is defined as a fetus that fails to achieve its genetically determined growth potential. The exact molecular mechanisms of placental insufficiency IUGR pathogenesis are a little known. Our goal was to identify key genes and gene co-expression modules related to placental insufficiency IUGR.

Methods

We used weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network analysis to examine the IUGR dataset GSE114691 from NCBI Gene Expression Omnibus. Core modules and hub nodes of the protein-protein interaction network were identified. A gene network was constructed and genes were classified by WGCNA into different modules. The validation of potential key genes was carried out using additiona

SUBMITTER: Zhang C 

PROVIDER: S-EPMC8796578 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature