MiR-199b-3p contributes to acquired resistance to cetuximab in colorectal cancer by targeting CRIM1 via Wnt/β-catenin signaling.

ABSTRACT:

Background

Despite advances in the development of efficient chemotherapy, the treatment of colorectal cancer (CRC) remains a challenge due to acquired chemoresistance. It has been reported that microRNAs (miRNAs) dysregulation is associated with the development of chemoresistance. Recently, the expression of miR-199b-3p has been found to be significantly different between cetuximab (CTx)-resistant and -sensitive CRC cells. However, its role and the underlying mechanisms in acquired chemoresistance to CTx in CRC are still obscure.

Methods

Here we report that miR-199b-3p is significantly up-regulated in both CTx-resistant (CTxR) CRC tissues and cell lines.

Results

Functional assays showed that suppressing miR-199b-3p could improve the sensitivity of CRC-CTxR cells to CT

SUBMITTER: Han H 

PROVIDER: S-EPMC8796585 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature