Genome-Wide association study of quantitative biomarkers identifies a novel locus for alzheimer's disease at 12p12.1.

ABSTRACT:

Background

Genetic study of quantitative biomarkers in Alzheimer's Disease (AD) is a promising method to identify novel genetic factors and relevant endophenotypes, which provides valuable information to deconvolute mechanistic complexity and better understand disease subtypes.

Results

Using the data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we performed a genome-wide association study (GWAS) between 565,373 single nucleotide polymorphisms (SNPs) and 16 key AD biomarkers from 1,576 subjects at four visits. We identified a novel locus rs5011804 at 12p12.1 significantly associated with several AD biomarkers, including three cognitive traits (CDRSB, FAQ, ADAS13) and one imaging trait (fusiform volume). Additional mediation and interaction analyses investigate

SUBMITTER: Lee B 

PROVIDER: S-EPMC8796646 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature