Characterizing non-exponential growth and bimodal cell size distributions in fission yeast: An analytical approach.

ABSTRACT: Unlike many single-celled organisms, the growth of fission yeast cells within a cell cycle is not exponential. It is rather characterized by three distinct phases (elongation, septation, and reshaping), each with a different growth rate. Experiments also showed that the distribution of cell size in a lineage can be bimodal, unlike the unimodal distributions measured for the bacterium Escherichia coli. Here we construct a detailed stochastic model of cell size dynamics in fission yeast. The theory leads to analytic expressions for the cell size and the birth size distributions, and explains the origin of bimodality seen in experiments. In particular, our theory shows that the left peak in the bimodal distribution is associated with cells in the elongation phase, while the right peak is due

SUBMITTER: Jia C 

PROVIDER: S-EPMC8797179 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature