Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study.

ABSTRACT:

Background

Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications. Children exposed to metformin vs. placebo in utero, have increased head circumference at birth and are more overweight and obese at 8 years of age. Also, maternal PCOS-status seems to alter the long-term cardio-metabolic health of offspring. We hypothesized that the long-term effects of metformin-exposure and/or maternal PCOS may be mediated by circulatory adaptations during fetal life.

Material and methods

This is a sub-study of a larger double-blinded, placebo-controlled trial, where women with PCOS were randomized to metformin (2g/day) or placebo in pregnancy, a total of 487 women. A sub-group of participants (N = 58) took part in this sub-study and had an

SUBMITTER: Grindheim S 

PROVIDER: S-EPMC8797196 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature