Comparative pathogenesis of different phylogroup I bat lyssaviruses in a standardized mouse model.

ABSTRACT: A plethora of bat-associated lyssaviruses potentially capable of causing the fatal disease rabies are known today. Transmitted via infectious saliva, occasionally-reported spillover infections from bats to other mammals demonstrate the permeability of the species-barrier and highlight the zoonotic potential of bat-related lyssaviruses. However, it is still unknown whether and, if so, to what extent, viruses from different lyssavirus species vary in their pathogenic potential. In order to characterize and systematically compare a broader group of lyssavirus isolates for their viral replication kinetics, pathogenicity, and virus release through saliva-associated virus shedding, we used a mouse infection model comprising a low (102 TCID50) and a high (105 TCID50) inoculation dose as well as t

SUBMITTER: Klein A 

PROVIDER: S-EPMC8797209 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature