The methylome in females with adolescent Conduct Disorder: Neural pathomechanisms and environmental risk factors.

ABSTRACT: Conduct Disorder (CD) is an impairing psychiatric disorder of childhood and adolescence characterized by aggressive and dissocial behavior. Environmental factors such as maternal smoking during pregnancy, socio-economic status, trauma, or early life stress are associated with CD. Although the number of females with CD is rising in Western societies, CD is under-researched in female cohorts. We aimed at exploring the epigenetic signature of females with CD and its relation to psychosocial and environmental risk factors. We performed HpaII sensitive genome-wide methylation sequencing of 49 CD girls and 50 matched typically developing controls and linear regression models to identify differentially methylated CpG loci (tags) and regions. Significant tags and regions were mapped to the respect

SUBMITTER: Chiocchetti AG 

PROVIDER: S-EPMC8797262 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature