Screening and verifying key genes with poor prognosis in colon cancer through bioinformatics analysis.

ABSTRACT:

Background

Colon cancer (CC) is one of the tumors with high morbidity and mortality in the world, and has a trend of younger generation. The molecular level of CC has not been fully elaborated. The purpose of this study is to screen and identify important genes with poor prognosis and their mechanisms at different levels.

Methods

GSE74602 and GSE10972 gene expression profiles were downloaded from the Gene Expression Omnibus (GEO) database. There were 58 normal tissues and 58 CC tissues. Differentially expressed genes (DEGs) were screened out by using the GEO2R tool and Venn diagram. Then, the DAVID online database was used to perform the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Six hub genes with the highest correlati

SUBMITTER: Dong B 

PROVIDER: S-EPMC8797306 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature