Development of a novel autophagy-related gene prognostic signature for gastric cancer.

ABSTRACT:

Background

A growing number of evidence has revealed the vital role of autophagy in pathological processes of cancer, including gastric cancer (GC). However, many previous studies only focused on exploring single pathway or limited genes of interest in GC, which only reflected partial functions of autophagy. The present study aimed to construct an autophagy-related risk signature for GC.

Methods

Differentially expressed autophagy-related genes (ARGs) in GC and non-tumor samples were screened through The Cancer Genome Atlas (TCGA) database, followed by bioinformatics analysis using the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) platforms. Prognosis-related ARGs were generated by univariate and multivariate Cox regression test.

Results

A t

SUBMITTER: Li F 

PROVIDER: S-EPMC8797385 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature