Comprehensive lncRNA and mRNA profiles in peripheral blood mononuclear cells derived from ankylosing spondylitis patients by RNA-sequencing analysis.

ABSTRACT:

Abstract

The present study aimed to investigate the comprehensive expression profiles of long non-coding RNA (lncRNA) in ankylosing spondylitis (AS).The peripheral blood samples were collected from 6 AS patients and 6 age- and gender-matched healthy controls (HCs), and separated for peripheral blood mononuclear cells, followed by RNA-sequencing. Further bioinformatics analyses were performed to explore the significantly enriched biological processes, signaling pathways of differentially expressed lncRNAs (DElncRNAs) (based on cis-target and trans-target genes) and differentially expressed mRNAs (DEmRNAs).Principal component analysis plots indicated that both lncRNA and mRNA expression profiles could distinguish AS patients from HCs; heatmap diagram exhibited a relatively good consi

SUBMITTER: Li C 

PROVIDER: S-EPMC8797511 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature