Whole-exome sequencing in cervical adenocarcinoma in mainland Chinese patients.

ABSTRACT:

Background

Cervical cancer is the most common gynecological malignancy worldwide. Adenocarcinoma is an important pathological type of cervical cancer. In recent years, the incidence of adenocarcinoma is rising in some countries and the prognosis of it remains poor. A precise description of the mutational landscape in cervical adenocarcinoma may provide insights into a better selection of treatments and improve prognosis.

Methods

In this study, we conducted whole-exome sequencing (WES) for cervical adenocarcinomas and matched blood samples from a cohort of 24 mainland Chinese patients. Additionally, the Human-Papilloma virus (HPV) infection statuses of these tumor samples were detected, and the genes that were enriched in both HPV positive and negative samples were also analy

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8797545 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature