The expression and prognostic value of RNA binding proteins in clear cell renal cell carcinoma.

ABSTRACT:

Background

RNA binding proteins (RBPs) have previously been demonstrated to be involved in the initiation and development of human cancers. However, its role in clear cell renal cell carcinoma (ccRCC) is not yet clear. The study was intended to explore the diagnostic and prognostic value of RBPs in ccRCC via bioinformatics methods of public datasets.

Methods

Data download from the Cancer Genome Atlas (TCGA) database was used to identify differentially expressed RBPs between normal renal samples and cancerous samples. Then, we performed the gene ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of differentially expressed genes (DEGs) using the ClusterProfiler package. Next, the protein-protein interaction (PPI) network wa

SUBMITTER: Li CX 

PROVIDER: S-EPMC8797574 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature