The utilization of immunotherapy with radiation therapy in lung cancer: a narrative review.

ABSTRACT: Despite decreasing smoking rates, lung cancer remains the leading cause of death from cancer in the United States. Radiation therapy has been established as an effective locoregional therapy for both early stage and locally advanced disease and is known to stimulate local immune response. Past treatment paradigms have established the role of combining cytotoxic chemotherapy regimens and radiation therapy to help address the local and systemic nature of lung cancer. However, these regimens have limitations in their tolerability due to toxicity. Additionally, cytotoxic chemotherapy has limited efficacy in preventing systemic spread of lung cancer. Newer systemic agents such as immune checkpoint inhibitors have shown improved survival in metastatic and locally advanced lung cancer and have th

SUBMITTER: Heinzerling JH 

PROVIDER: S-EPMC8797746 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature