Resveratrol affects the migration and apoptosis of monocytes by blocking HMGB1/NF-κB pathway.

ABSTRACT:

Background

Chronic inflammation is now recognized as a causal factor of aging. Resveratrol is a non-flavonoid compound that widely exists in plant species, exerting anti-inflammatory effects in vitro and in animal models. The chemotaxis of inflammatory cells and secretion of cytokines are key characters in inflammation response.

Methods

The effects of lipopolysaccharide (LPS) and high mobility group box-1 (HMGB1) chromosomal on the migration, inflammatory response, and apoptosis of monocytes were detected. THP-1 cells were used to study the effects of resveratrol treatment on LPS- and HMGB-induced monocytes. We aimed to investigate the effect of Resveratrol on monocyte migration and the expression of a special cytokine named HMGB1 in THP-1 cells.

Results

Resveratrol o

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8797930 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature