A retrospective analysis of the correlation between AXL expression and clinical outcomes of patients with urothelial bladder carcinoma.

ABSTRACT:

Background

Immunohistochemistry (IHC) analysis of primary tumors revealed that AXL expression is associated with survival in patients with different cancers. The objective of our study is to investigate the relationship between the expression of AXL and clinical outcomes of patients with bladder carcinoma (BC).

Methods

A total of 407 samples from The Cancer Genome Atlas (TCGA) database and 203 patients with clinical and pathological diagnosis of BC in our hospital were used to assess the association of AXL and clinical outcomes of BC patients. IHC was performed to evaluate the expression of AXL in tumor tissue collected after surgical treatment.

Results

Data from TCGA showed that AXL mRNA expression was significantly associated with poor clinical-pathological c

SUBMITTER: Wang L 

PROVIDER: S-EPMC8798078 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature