The association between genomic variations and histological grade in hepatocellular carcinoma.

ABSTRACT:

Background

Histological grade (HG) is an important prognostic factor for hepatocellular carcinoma. With the development of precision medicine, diagnosis with a sequencing technology has become increasingly accepted. It is vital to discuss their similarities and differences to bridge or improve the traditional HG diagnosis with the novel sequencing technique.

Methods

A total of 658 tumor samples were collected from 602 Chinese hepatocellular carcinoma patients and sequenced for a panel of pan-cancer genes. Nucleotide usage bias, genomic variation-related scores, driver genes, and biological processes were compared among different HGs. These results were further verified using a cohort dataset from the Western population.

Results

Genomic variation subtypes, such as C>G

SUBMITTER: Liu J 

PROVIDER: S-EPMC8798104 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature