New prognostic models for extranodal natural killer T-cell lymphoma, nasal-type using Cox regression and machine learning.

ABSTRACT:

Background

The prognostic index of natural killer lymphoma (PINK) is recommended for use as a prognostic model for determining the best non-anthracycline-based treatment for extranodal natural killer T-cell lymphoma, nasal-type (ENKTL). However, this model does not provide an accurate individual risk estimation for patients; therefore, our retrospective study was conducted to determine this risk.

Methods

Clinical data from 250 patients with ENKTL treated with non-anthracycline-based regimens were analyzed. The statistically significant clinical characteristics were selected as the parameters for our models. The patient data from 250 patients were randomly divided into 5 groups for 5-fold cross validation before final models were established on all of the patients' data. A st

SUBMITTER: Sun J 

PROVIDER: S-EPMC8798130 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature