Tamoxifen side effects: pharmacogenetic and clinical approach in Mexican mestizos.

ABSTRACT:

Background

Tamoxifen metabolism is translated into four genetic phenotypes (GP): genetic poor metabolizer (gPM); genetic intermediate metabolizer (gIM); genetic normal metabolizer (gNM); and genetic ultra-rapid metabolizer (gUM). Although CYP2D6 is involved in tamoxifen biotransformation, its association with tamoxifen side effects (TSE) is limited. Therefore, we evaluated CYP2D6 GP and clinical variables as potential predictors of TSE in Mexican Mestizo patients.

Methods

This cross-sectional study evaluated CYP2D6 GP, clinical data, and self-reported TSE in 71 women. Potential predictors were tested in uni- and multivariable models.

Results

Hot flashes (57.75%), arthralgia (45.07%), headache (43.66%), and cramps (39.44%) were the most frequent TS

SUBMITTER: Rangel-Mendez JA 

PROVIDER: S-EPMC8798170 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature