An investigation to identify tumor microenvironment-related genes of prognostic value in lung squamous cell carcinoma based on The Cancer Genome Atlas.

ABSTRACT:

Background

Lung squamous cell carcinoma (LUSC) is a prevalent and lethal malignancy with a poor clinical prognosis. Major constituents of the tumor microenvironment (TME) include infiltrating immune cells and stromal cells, which play a pivotal role in the progression and growth of the disease. To improve the understanding of the prognostic influence of immune and stromal cell-related genes for patients with the disease, we performed a comprehensive bioinformatics analysis to identify TME-relevant biomarkers, and investigated the potential role of these candidate signatures in LUSC.

Methods

Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) assessed the samples of LUSC obtained from The Cancer Genome Atlas (TCGA). The samples w

SUBMITTER: Liu H 

PROVIDER: S-EPMC8798203 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature