Exploring the molecular targets and mechanisms of [10]-Gingerol for treating triple-negative breast cancer using bioinformatics approaches, molecular docking, and in vivo experiments.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is the most aggressive among breast cancer subtypes with the worst prognosis. Ginger is widely used in pharmaceuticals and as food. Its anticancer properties are known, but the mechanism is still unclear. [10]-Gingerol is one of the main phenolic compounds isolated from ginger. Studying the biological effects of [10]-Gingerol is of great significance to understand the efficacy of ginger.

Methods

In this study, the therapeutic effects of [10]-Gingerol on TNBC cells were studied using network pharmacology, molecular docking, and in vitro experiments, and the target and mechanism of action were explained.

Results

A total of 48 targets of ginger for the treatment of TNBC were found. These targets might interfere with the gro

SUBMITTER: Huang P 

PROVIDER: S-EPMC8798581 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature