Downregulation of ARID1A is correlated with poor prognosis in non-small cell lung cancer.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is the main type of lung cancer and NSCLC patients always have a low 5-year survival rate. It is vital to identify a biomarker for the prognosis of NSCLC patients. AT-rich interaction domain 1a (ARID1A) is a tumor suppressor that is involved in the progression of a variety of tumors.

Methods

The ARID1A protein level in NSCLC tissues and paracancerous normal lung (PCNL) tissues were detected with immunohistochemistry (IHC) and western blotting (WB). The χ² test and Spearman's rank correlation analysis were carried out to examine the association between ARID1A expression and the clinicopathological features of NSCLC. The Kaplan-Meier method and log-rank test were used to compare overall survival (OS) in the ARID1A low ex

SUBMITTER: Wang T 

PROVIDER: S-EPMC8798606 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature