Overexpression of SEZ6L2 predicts poor prognosis in patients with cholangiocarcinoma.

ABSTRACT:

Background

With the feature of destructive and biliary malignancy, intrahepatic cholangiocarcinoma (ICC), presents unclear molecular mechanisms which contributes to typically poor prognosis for patients. Seizure-related 6 homolog-like 2 (SEZ6L2) is a gene that encodes for a seizure-associated protein localized on the cell surface. Thus far, the function of SEZ6L2 in ICC has not been reported.

Methods

We used data from The Cancer Genome Atlas and the Gene Expression Omnibus to analyze dynamics behind and levels of expression of SEZ6L2 in ICC. Then we used qRT-PCR and Immunohistochemical staining to detect levels of expression of SEZ6L2 and thereby determined the potential clinical significance of this protein in ICC.

Results

According

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8798643 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature