Genome-wide expression changes mediated by A-to-I RNA editing correlate with hepatic oncogenesis.

ABSTRACT:

Background

Adenosine-to-inosine (A-to-I) RNA editing is one of the most prevalent RNA modifications in the animal kingdom. Since inosine is recognized as guanosines, the A-to-I process mimics A-to-G DNA mutations but can be controlled in a more flexible manner compared to DNA alterations.

Methods

We parsed the transcriptomes and translatomes of liver cancer and normal tissues from ten patients. We profiled the landscape of the A-to-I RNA editome in these samples and interrogated whether the A-to-I processes participated in the gene expression regulation in oncogenesis.

Results

Globally, editing activity was enhanced in all tumor samples compared to that in normal samples. Accordingly, expression of the gene encoding the RNA editing enzyme ADAR (adenosine deaminase act

SUBMITTER: Li J 

PROVIDER: S-EPMC8798912 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature