MiRNA-425-5p enhances diffuse large B cell lymphoma growth by targeting PTEN.

ABSTRACT:

Background

At present, cancer is one of the greatest threats to mankind, and is associated with the highest rates of morbidity and comorbidity. Recently, the advancements in molecular biology have led to an in-depth understanding of the underlying pathophysiology, which may further impact the lead time in the context of early discovery and effective therapy of cancer. Therefore, the present study proposes a better understanding of the role of micro(miR)-425-5p in diffuse large B-cell lymphoma (DLBC).

Methods

qRT-PCR was carried out to detect the relevant proteins, miRNA and mRNA RNA gene expression in DLBC cells. The effect of miR-425-5p on DLBC growth was examined by CCK-8 and colony formation assays. The binding relationship between genes was verified by dual-luciferase re

SUBMITTER: Wu W 

PROVIDER: S-EPMC8799000 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature