Associations between polymorphisms in genes of base excision repair pathway and lung cancer risk.

ABSTRACT:

Background

The correlation between at-risk polymorphisms in genes of base excision repair (BER) pathways and lung cancer (LC) risk was newly considered but still not clear, a systematic review and updated meta-analysis was performed in the current study.

Methods

We identified and recorded the eligible publications from Google Scholar, PubMed, Medicine and Web of Science. For all calculates, odds ratios (ORs) and 95% confidence intervals (CIs) were applied to estimate the potential relationship between these genetic variants and LC risk. Subsequently, Begg's funnel plot and Egger's test were used to appraising the publication bias.

Results

A total of 202 case-control studies extracted from 116 publications were enrolled. Firstly, we analyzed six polymorphisms in XRC

SUBMITTER: Liu S 

PROVIDER: S-EPMC8799111 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature