COL4A family: potential prognostic biomarkers and therapeutic targets for gastric cancer.

ABSTRACT:

Background

The type IV collagen alpha chain (COL4A) family is a major component of the basement membrane (BM) that has recently been found to be involved in tumor angiogenesis and progression. However, the expression levels and the exact roles of distinct COL4A family members in gastric cancer (GC) have not been completely understood.

Methods

Here, the expression levels of COL4As in GC and normal gastric tissues were calculated by using TCGA datasets and the predicted prognostic values by the GEPIA tool. Furthermore, the cBioPortal and Metascape tools were integrated to analyze the genetic alterations, correlations and potential functions of COL4As, and their frequently altered neighboring genes in GC.

Results

Notably, the expression levels of COL4A1/

SUBMITTER: Zeng X 

PROVIDER: S-EPMC8799138 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature