The Notch1 gene may control cell chemoresistance in esophageal squamous cell cancer.

ABSTRACT:

Background

In our previous study, missense mutations in the Notch1 gene were found in chemotherapy-resistant esophageal squamous cell cancer (ESCC) patients. In this study, we explored changes in the interaction between Notch1 and DLL4 resulting from missense mutations.

Methods

Bioinformatics analysis was performed to assess and compare the different biological structures and functions of wild type (WT) and mutation type (MT) sequences of Notch1. A genetic information search was performed, and the results were analyzed using in silico modeling. Homology modeling of the Notch1 protein was carried out using Swiss-Model software, and modeling of site-directed mutations was carried out using PyMOL software to observe the protein structure. The Notch1-DLL4 ligand-receptor complex

SUBMITTER: Gao K 

PROVIDER: S-EPMC8799163 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature