SNP rs2240688 in CD133 gene on susceptibility and clinicopathological features of hepatocellular carcinoma.

ABSTRACT:

Background

CD133 is one of the important cancer stem cells (CSCs) markers of hepatocellular carcinoma (HCC). The aim of this study was to explore the relationship between CD133 single-nucleotide polymorphisms (SNPs) and risk factors associated with HCC susceptibility and clinicopathological features in HCC cases and healthy controls from the Guangxi region of southern China.

Methods

A case control study was conducted, including 565 HCC patients and 561 control subjects. The genotyping of rs2240688 was performed using the SNaPshot method. Unconditional logistic regression was used to correct for gender, age, and other confounding factors. Odds ratio (OR) and its 95% confidence interval (CI) were calculated to analyze the relationship between allele and genotype frequency and

SUBMITTER: Pan X 

PROVIDER: S-EPMC8799249 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature