Comprehensive analysis reveals a four-gene signature in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the major malignant diseases of the gastrointestinal system around the world. However, the current therapeutic regimens were not always effective. This study was designed to identify and depict potential molecular biomarkers and correlated signal pathways in CRC.

Methods

The gene expression profiles of GSE21510 were obtained on the Gene Expression Omnibus website, we filtered out 44 samples from the GSE21510 to identify different expression genes (DEGs) between CRC tissues and noncancerous tissues. Subsequently, the function and signal pathways enrichment analyses were implemented, the protein-protein interaction (PPI) networks of DEGs were to be carried out, and the hub genes were screened by MCODE built in Cytoscape software. La

SUBMITTER: Zhao B 

PROVIDER: S-EPMC8799256 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature