Mechanism of Sanhua Decoction in the Treatment of Ischemic Stroke Based on Network Pharmacology Methods and Experimental Verification.

ABSTRACT:

Objective

The mechanism of action of Sanhua Decoction (SHD) in the treatment of ischemic stroke (IS) was analyzed based on the network pharmacology technology, and the pharmacodynamics and key targets were verified using the rat middle cerebral artery occlusion (MCAO) model.

Methods

The GEO database was used to collect IS-related gene set S _D , and DrugBank and TTD databases were used to obtain the therapeutic drug target set S _T . IS disease gene set S _I was collected from DisGeNET, GeneCards, and OMIM databases. These three different gene sets obtained from various sources were merged, duplicates were removed, and the resulting IS disease gene set S _IS was imported into the STRING

SUBMITTER: YingHuang 

PROVIDER: S-EPMC8799339 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature