Assessing the accuracy of the lung allocation score.

ABSTRACT:

Background

The United States (US) Lung Allocation Score (LAS) relies on the performance of 2 survival models that estimate waitlist and post-transplant survival. These models were developed using data from 2005 to 2008, and it is unknown if they remain accurate.

Methods

We performed an observational cohort study of US lung transplantation candidates and recipients greater than 12 years of age between February 19, 2015 and February 19, 2019. We evaluated the LAS waitlist and post-transplant models with the concordance probability estimate and by comparing predicted vs observed 1-year restricted mean survival times by risk decile. We then compared a nonparametric estimate of the observed LAS with the predicted LAS for each percentile of recipients.

Results

The waitlist

SUBMITTER: Parker WF 

PROVIDER: S-EPMC8799497 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature