Effects of colchicine on lipolysis and adipose tissue inflammation in adults with obesity and metabolic syndrome.

ABSTRACT:

Objective

The aim of this study was to examine whether colchicine's anti-inflammatory effects would improve measures of lipolysis and distribution of leukocyte populations in subcutaneous adipose tissue (SAT).

Methods

A secondary analysis was conducted for a double-blind, randomized, placebo-controlled pilot study in which 40 adults with obesity and metabolic syndrome (MetS) were randomized to colchicine 0.6 mg or placebo twice daily for 3 months. Non-insulin-suppressible (l₀ ), insulin-suppressible (l₂ ), and maximal (l₀ +l₂ ) lipolysis rates were calculated by minimal model analysis. Body composition was determined by dual-energy x-ray absorptiometry. SAT leukocyte populations were characterized by flow cytometry analysis from bi

SUBMITTER: Levine JA 

PROVIDER: S-EPMC8799499 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature