Biomarkers associated with mortality in pediatric patients with cardiac arrest and acute respiratory distress syndrome.

ABSTRACT:

Aims

To identify plasma biomarkers associated with cardiac arrest in a cohort of children with acute respiratory distress syndrome (ARDS), and to assess the association of these biomarkers with mortality in children with cardiac arrest and ARDS (ARDS + CA).

Methods

This was a secondary analysis of a single-center prospective cohort study of children with ARDS from 2014-2019 with 17 biomarkers measured. Clinical characteristics and biomarkers were compared between subjects with ARDS + CA and ARDS with univariate analysis. In a sub-cohort of ARDS + CA subjects, the association between biomarker levels and mortality was tested using univariate and bivariate logistic regression.

Results

Biomarkers were measured in 333 subjects: 301 with ARDS (median age 5.3 years, 55.5% m

SUBMITTER: Gardner MM 

PROVIDER: S-EPMC8799511 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature