A20 undermines alternative NF-κB activity and expression of anti-apoptotic genes in Helicobacter pylori infection.

ABSTRACT: A hallmark of infection by the pathogen Helicobacter pylori, which colonizes the human gastric epithelium, is the simultaneous activation of the classical and alternative nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways, underlying inflammation and cell survival. Here, we report that the classical NF-κB target gene product A20 contributes to the negative regulation of alternative NF-κB signaling in gastric epithelial cells infected by H. pylori. Mechanistically, the de novo synthesized A20 protein interacts with tumor necrosis factor receptor-associated factor-interacting protein with forkhead-associated domain (TIFA) and thereby interferes with the association of TIFA with the NIK regulatory complex. We also show that alternative NF-κB activity contributes t

SUBMITTER: Lim MCC 

PROVIDER: S-EPMC8799570 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature