Identification of a clonal population of Aspergillus flavus by MALDI-TOF mass spectrometry using deep learning.

ABSTRACT: The spread of fungal clones is hard to detect in the daily routines in clinical laboratories, and there is a need for new tools that can facilitate clone detection within a set of strains. Currently, Matrix Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry is extensively used to identify microbial isolates at the species level. Since most of clinical laboratories are equipped with this technology, there is a question of whether this equipment can sort a particular clone from a population of various isolates of the same species. We performed an experiment in which 19 clonal isolates of Aspergillus flavus initially collected on contaminated surgical masks were included in a set of 55 A. flavus isolates of various origins. A simple convolutional neural network (CNN) was tr

SUBMITTER: Normand AC 

PROVIDER: S-EPMC8799650 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature