Contribution of obesity and cardiometabolic risk factors in developing cardiovascular disease: a population-based cohort study.

ABSTRACT: This study aims to assess the effects of central and general adiposity on development of cardiovascular diseases (CVDs) mediated by cardiometabolic risk factors and to analyze their degree of dependency for mediating their effects. To this end, data from the the Tehran Lipid and Glucose Study cohort with 6280 participants were included in this study. The hazard ratios were calculated using a 2-stage regression model in the context of a survival model. Systolic blood pressure (BP), total serum cholesterol, and fasting plasma glucose were designated as mediators. Assessing the interactions revealed that BP was the most important mediator for general ( (HR_NIE: 1.11, 95% CI 1.17-1.24) and central obesity (CO) (HR_NIE: 1.11, 95% CI 1.07-1.15) with 60% and 36% proportion of

SUBMITTER: Bakhtiyari M 

PROVIDER: S-EPMC8799723 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature